Alain Guillaume

Jan 14, 2022

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Alain Guillaume

Professeur des Universités

alain.guillaume@u-paris.fr

0176533158

4030

SCIENTIFIC ACTIVITIES

Research interest

Visuo-motor integration, Sensori-motor adaptation, Attention, Decision making,
Bayesian brain, Active inference, Reactive and voluntary behavioral control, Eye
movements, Eye dominance.
Psychophysics, Neurophysiology (fmri, eeg), Computational neurosciences, Deep-
learning.
Vision is a major channel through which we acquire information about our environment. Consequently, eye movements—which orient our highly sensitive fovea toward stimuli of interest—are a central topic in cognitive science.
Our research explores how low-level and high-order processes interact, between them and with visual scene characteristics, to shape overt attentional control. For example, we study visual system lateralization, commonly referred to as eye dominance, as a low-level functional factor influencing attention. We also examine how information distribution within visual scenes implicitly influences decision-making and oculomotor control. Another major focus of our work is oculomotor learning mechanisms such as saccadic adaptation and reward-based learning processes, where information itself serves as a reinforcement signal.
Our approach is primarily behavioral, studying eye movement control in humans, but we integrate computational modeling and neurophysiological approaches (fMRI and EEG) to provide complementary insights into these mechanisms.

Publications

Articles

  • Desbordes, T. J., Alahyane, N., & Guillaume, A. (2025). Task-relevant information availability shapes eye movements and perceptual judgment confidence. Scientific Reports, 15(1), 31695.
  • Chaumillon, R., Alahyane, A., Senot, P., Lemoine-Lardennois, C., Doré-Mazars, K., Vergilino-Perez, D., Guillaume, A. (2022). Distractor-induced saccade trajectory curvature reveals visual contralateral bias with respect to the dominant eye. Scientific Reports, 12 (1), pp.21737. ⟨10.1038/s41598-022-26319-3⟩. ⟨hal-03974696
  • Schintu, S., Chaumillon, R., Guillaume, A., Salemme, R., Reilly, KT., Pisella, L., Farne, A. Eye dominance modulates visuospatial attention (2019). Neuropsychologia, in press, 2019. doi: 10.1016/j.neuropsychologia.2019.107314
  • Guillaume, A., Fuller, J., Srimal, R. and Curtis, CE (2018). Cortico-cerebellar network involved in saccade adaptation. J. Neurophysiol. 120(5):2583–2594, 2018. doi: 10.1152/jn.00392.
  • Chaumillon, R., Blouin, J. and Guillaume A. (2018). Interhemispheric transfer time asymmetry of visual information depends on eye dominance: an electrophysiological study. Frontiers in Neuroscience 12:72, 2018. doi : 10.3389/fnins.2018.00072.
  • Chaumillon, R., Alahyane, N., Senot, P., Vergne, J., Lemoine-Lardennois, C., Blouin, L., Doré-Mazars, K., Guillaume, A.* and Vergilino-Perez, D* (2017). Asymmetry in visuo-motor processing depends on the strength of eye dominance. Neuropsychologia 96: 129-136 doi: 10.1016/j.neuropsychologia.2017.01.015, 2017. (*AG and DVP should be considered as co-last authors).
  • Megardon, G., Tandonnet, C., Sumner, P., Guillaume, A. (2015). Limitations of short range Mexican hat connection for driving target selection in a 2D neural field: activity suppression and deviation from input stimuli. Front Comput Neurosci. doi: 10.3389/fncom.2015.00128
  • Lebar, N., Bernier, P.M., Guillaume, A., Mouchnino, L. and Blouin, J. Neural correlates for task-relevant facilitation of visual inputs during visually-guided hand movements. Neuroimage 121: 39-50, 2015.
  • Chaumillon, R., Alahyane, N., Senot, P., Vergne, J., Lemoine-Lardennois, C., Doré-Mazars K., Blouin, J., Vergilino-Perez, D., Guillaume, A. Toward an eye dominance quantification for better management of eye diseases. French Journal of Ophtalmology 38(4): 322-332, 2015. [in French].
  • Blouin, J., Saradjian, A., Guillaume, A. and Mouchnino, L. Opposed optimal strategies of weighting somatosensory inputs when aiming for visual and proprioceptive targets. J Neurophysiol 112(9): 2290-301, 2014.
  • Chaumillon, R, Blouin, J. and Guillaume A. Eye dominance influences triggering action: the Poffenberger paradigm revisited. Cortex 58: 86-98, 2014.
  • Guillaume, A. Saccadic inhibition is accompanied by large and complex amplitude modulations when induced by visual backward masking. Journal of Vision, 12(6).pii:5: 1-20, 2012.
  • Cotti, J., Vercher, JL., Guillaume, A. Hand-eye coordination relies on extra-retinal signals : evidence from reactive saccade adaptation. Behavioural Brain Research 218(1): 248-252, 2011.
  • Mouraud, A., Guillaume, A., Paugam-Moisy, H. The DAMNED simulator for implementing a dynamic model of the network controlling saccadic eye movements. (International conference paper) In Proc. of ICANN Artificial Neural Networks, Springer, Thessaloniki, Greece, September 2010. Lecture notes in Computer Science 6352: 272-281, 2010.
  • Cotti, J., Panouilleres, M., Munoz, DP., Vercher, JL., Pélisson, D., Guillaume, A. Adaptation of reactive and voluntary saccades: different patterns of adaptation revealed in the antisaccade task. Journal of Physiology 587: 127-138, 2009.
  • Cotti, J., Guillaume, A., Alahyane, N., Pelisson D, and Vercher, JL. Adaptation of Voluntary Saccades, but not of Reactive Saccades, Transfers to Hand Pointing Movements. J. Neurophysiol. 98: 602-612, 2007.
  • Alahyane, N., Salemme, R., Urquizar, C., Cotti, J., Guillaume, A., Vercher, JL. and Pélisson, D. Oculomotor plasticity: are mechanisms of adaptation for reactive and voluntary saccades separate? Brain. Res. 1135(1): 107-121, 2007.
  • Guillaume A and PElisson D Kinematics and eye-head coordination of gaze shifts evoked from different sites in the superior colliculus of the cat. J. Physiol. 577: 779-794, 2006.
  • Pélisson, D., Goffart, L. and Guillaume, A. Control of saccadic eye movements and combined eye/head gaze shifts by the medio-posterior cerebellum. Prog. in Brain Res. 142: 69-89, 2003.
  • Pélisson, D., Goffart, L., Guillaume, A. and Quinet, J. Visuo-motor deficits induced by fastigial nucleus inactivation. The Cerebellum 2: 71-76, 2003.
  • Guillaume, A. and Pélisson, D. Properties and Cerebellar Control of the Superior Colliculus Motor Map in the Head-Unrestrained Cat. Cahiers de Psychologie Cognitive / Current Psychology of Cognition 21(4-5): 397-435, 2002.
  • Guillaume, A. and Pélisson, D. Gaze shifts evoked by electrical stimulation of the superior colliculus in the head-unrestrained cat. I. Effect of the locus and of the parameters of stimulation. Eur. J. Neurosci.14: 1331-1344, 2001a.
  • Guillaume, A. and Pélisson, D. Gaze shifts evoked by electrical stimulation of the superior colliculus in the head-unrestrained cat. II. Effect of muscimol inactivation of the caudal fastigial nucleus. Eur. J. Neurosci.14: 1345-1359, 2001b.
  • Pélisson, D., Goffart, L., Guillaume, A., Catz, N. and Raboyeau, G. Early head movements elicited by visual stimuli or collicular electrical stimulation in the cat. Vision Res. 41: 3283-3294, 2001.
  • Guillaume, A., Goffart, L., Courjon, J. and Pélisson, D. Altered visuo-motor behavior during inactivation of the caudal fastigial nucleus in the cat. Exp. Brain Res. 132: 457-463, 2000.
  • Guillaume, A., Goffart, L. and Pélisson, D. Learning from cerebellar lesions about the temporal and spatial aspects of saccadic control. Commentaire sur l’article: Findlay JM and Walker R A model of saccade generation based on parallel processing and competitive inhibition. Behav. and Brain Sci. 22(4): 687-688, 1999.
  • Goffart, L., Guillaume, A. and Pélisson, D. Compensation for gaze perturbation during inactivation of the caudal fastigial nucleus in the head-unrestrained cat. J. Neurophysiol. 80: 1552-1557, 1998.
  • Pélisson, D., Goffart, L. and Guillaume, A. Contribution of the rostral fastigial nucleus to the control of orienting gaze shifts in the head-unrestrained cat. J. Neurophysiol. 80: 1180-1196, 1998.
  • Goffart, L., Pélisson, D. and Guillaume, A. Orienting gaze shifts during muscimol inactivation of the caudal fastigial nucleus in the cat. II. Dynamics and eye-head coupling. J. Neurophysiol. 79: 1959-1976, 1998.

Chapitre d’ouvrage

  • Pélisson, D. and Guillaume, A. Eye-Head Coordination. In M. D. Binder, N. Hirokawa & U. Windhorst (Eds.), Encyclopedia of Neuroscience, Heidelberg, Germany: Springer. 2008.

Communications

Communications orales avec actes dans des congrès internationaux

  • Dauce, E., Mouraud, A., Guillaume, A. Simple spatio-temporal transformation with sub-threshold integration in the saccadic system. Proc. of the Twentieth Annual Computational Neuroscience Meeting: CNS*2011, Stockholm, Sweden, July 23-28, BMC Neuroscience 12(Suppl 1):P133, 2011.
  • Cotti, J., Vercher, J-L., Guillaume, A. Adaptation of voluntary saccades affects visual target localization for movement production but not for perceptual judgment. Soc. Neurosci. Abstr.: 555.1: 3-7 Nov., San Diego, USA, 2007.
  • Guillaume, A. and Pélisson, D. Saccadic gaze shifts evoked by electrical stimulation of the superior colliculus following caudal fastigial nucleus inactivation in the cat. Soc. Neurosci. Abstr.: 23-28 Oct., Miami, USA, 1999.

Communication affichées récentes dans des congrès nationaux / internationaux

  • Desbordes, T. J., Alahyane, A., & Guillaume, A. (2024, February). How does learning epistemic value influence saccade behaviors? [Poster session] GDR Vision, Grenoble, France.
  • Desbordes, T. J., Alahyane, A., & Guillaume, A. (2024, August). Task-relevant information availability guides saccadic decision and performance [Poster session] European Conference on Visual Perception, Aberdeen, United Kingdom.

Communications orales sur invitation

  • Guillaume, A. The eye dominance: an overlooked lateralization? Center for Neural Science Seminar Series, Queen’s University, Kingston, Canada, 9 mars 2016.
  • Guillaume, A. Neural bases of learning in the saccadic eye movement system. Center for Neural Science, Friday Fights, Queen’s University, Kingston, Canada, 26 février 2016.
  • Guillaume, A. Influence de la dominance oculaire au niveau de la visuo-motricité : données comportementales et électrophysiologiques. Séminaire Centre de Recherche en Neurosciences de Lyon – Inserm U1028, CNRS UMR5292 , Lyon 21 mars 2013.
  • Guillaume, A. Utiliser des distracteurs pour mieux comprendre l’intégration visuo-motrice au niveau du système saccadique. GDR Robotique ” Robotics and Neuroscience ” Day 2 ISIR, Paris 30 novembre 2012.
  • Guillaume, A. and Chaumillon, R. Le paradigme de Poffenberger revisité : données comportementales et électrophysiologiques en faveur d’un impact de la dominance oculaire. Séminaire Laboratoire Vision Action Cognition – FRE 3292, Paris 8 novembre 2012.
    Dauce, E., Mouraud, A., Guillaume, A. Simple spatio-temporal transformation with sub-threshold integration in the saccadic system. Proc. of the Twentieth Annual Computational Neuroscience Meeting: CNS*2011, Stockholm, Sweden, July 23-28, BMC Neuroscience 12(Suppl 1):P133, 2011.
  • Guillaume, A. Masquage visuel dans un système sensori-moteur. Séminaire Laboratoire de Neurosciences Cognitives LNC – UMR 6155, Marseille 15 mars 2010.
  • Guillaume, A. and Cotti, J. Saccadic adaptation and its transfer to hand pointing movement. Journées Scientifiques LNPCog – Université Paris Descartes, Paris 26-27 mars 2007.
  • Cotti, J., Vercher, J-L., Guillaume, A. Adaptation of voluntary saccades affects visual target localization for movement production but not for perceptual judgment. Soc. Neurosci. Abstr.: 555.1: 3-7 Nov., San Diego, USA, 2007.
  • Guillaume, A. and Cotti, J. Motricité réactive et volontaire : Transfert d’adaptation des saccades oculaires aux mouvements de pointage manuel. Séminaire INCM – UMR 6193, Marseille 16 décembre 2005.
  • Guillaume, A, Cotti, J., Pélisson, D. and Vercher, JL. Contrôle en ligne et adaptatif des saccades oculaires Séminaire Centre de Recherche Cerveau et Cognition – UMR 5549, Toulouse 11 juin 2004.
  • Guillaume, A, Cotti J., Pélisson, D. and Vercher, JL. Contrôle immédiat et adaptatif des saccades oculaires Séminaire INSERM U534 Espace et Action, Lyon 1 juillet 2004.
  • Guillaume, A. and Pélisson, D. Saccadic gaze shifts evoked by electrical stimulation of the superior colliculus following caudal fastigial nucleus inactivation in the cat. Soc. Neurosci. Abstr.: 23-28 Oct., Miami, USA, 1999.

Responsabilités pédagogiques

  • Responsable de l’UE APR3 de formation à la méthodologie expérimentale par la pratique (L2) (2021-)
  • Co-Responsable (avec L. Lavergne) de l’UE M1 PCFA Perception action expertise (2021-)
  • Responsable du TER L3 “Informations visuelles et comportement” (2019-)
  • Responsable du dispositif “L’évaluation des formations et des enseignements par les étudiants (EFEE)” pour la Faculté des Sciences du Sport (https://deve.univ-amu.fr/ove/Evaluation). De sept 2016 à Août 2019.
  • Responsable de l’Unité d’Enseignement “Méthodologie du Travail Universitaire “, destinée aux étudiants de Licence 1. de Sept. 2010 à Juin 2013.
  • Responsable du parcours “Sciences du Mouvement Humain et du Sport” (SMHS) de la Licence STAPS de la Faculté des Sciences du Sport, Aix-Marseille Université , de Sept. 2004 à Juin 2007.
  • Délégué aux Relations Internationales pour la Faculté des Sciences du Sport, Aix-Marseille Université, de Septembre 2001 à Juin 2004.

 

  • Responsabilités administratives
  • Membre suppléant du Conseil de l’Ecole Doctorale (2021–)
  • Membre du Conseil de Laboratoire de l’EA 7326, Université Paris Cité, (2019- )
  • Membre élu du Conseil de Laboratoire de l’UMR 7291, Aix-Marseille Université, de Déc. 2011 à Août 2013
  • Membre élu du CA de la Faculté des Sciences du Sport, Aix-Marseille Université, de Novembre 2005 à Décembre 2009.
  • Membre élu du Conseil de Laboratoire de l’UMR 6152 (devenu Institut des Sciences du Mouvement), Aix-Marseille Université, de Mars 2004 à Décembre 2007.